Avastin® (bevacizumab), 100mg/4mL and 400mg/16 mL vials, is a Prescription Medicine used to treat metastatic (spreading) colorectal, kidney, breast, brain and lung cancers. Do not use Avastin if: you have had an allergic reaction to Avastin, any of its ingredients or other antibodies, or if you have been coughing or spitting up blood. Tell your doctor if: you are pregnant or breast-feeding, or plan to become pregnant or breast-feed, you have inflammation of the bowel or stomach ulcers, high blood pressure, a history of bleeding, blood clots, low white blood cells (neutropenia), stroke or bleeding in your lungs, have had major surgery in the last 28 days or a wound that has not healed properly, have heart disease, have/have had a fistula, have ever received anthracyclines (e.g. doxorubicin) for cancer or radiotherapy to your chest, you are >65 years of age, or you are taking any other medicines. Possible unwanted effects include: Common: high blood pressure (symptoms include, blurred vision, ringing in the ears), body pain, tiredness/weakness, diarrhoea, constipation or rectal bleeding, sore mouth or mouth ulcers, loss of appetite, being thirsty, shortness of breath, runny, blocked or bleeding nose, dry, scaling or inflamed skin, change in skin colour, taste changes, blurred vision or other eye problems, dizziness/faintness, headache, changes in your voice or difficulty speaking. Serious (rare): severe body or stomach pain or cramps, headache, severe diarrhoea, nausea and vomiting, coughing or spitting up blood, clots in the veins of the legs, pain and/or swelling in the lower legs, feet or hands, severe bleeding or problems with your wound healing, seizures, sleepiness/drowsiness, abcesses (pus-filled sores), feeling of numbness or tingling in feet or hands, dry mouth with thirst and/or darkened urine, increased heart rate, shortness of breath, symptoms of an allergic reaction which may include shortness of breath, wheezing or difficulty breathing, swelling of the face, lips, tongue or other parts of the body, or rash, itching or hives on the skin. Ask your oncologist if Avastin is right for you. Use strictly as directed. If symptoms continue or if you experience side effects or would like further information, please talk to your oncologist or pharmacist, or visit www.medsafe.govt.nz for Avastin Consumer Medicine Information. Avastin is not a cure for cancer. Avastin is an unfunded medicine. You will need to pay for this medicine. A prescription charge and normal oncologist fees apply. Consumer panel based on CMI dated 21 December 2012

Roche Products (New Zealand) Limited, Auckland. Phone: 0800 656 464. www.roche.co.nz. All trademarks mentioned herein are protected by law.

For more information please view the Avastin Consumer Medicine Information. Access to this site is subject to the terms in our Legal Statement; you accept these terms by continuing to access this site. ID1466/DA3013ER/2013FEB

This website was last updated on February 2013. © 2009 Roche Products (New Zealand) Ltd.